Alendronate可增加对间隙性Etidronate无反应的绝经后骨质疏松妇女的脊柱与髋部骨密度

• 作 者: 何海龙
• 出 处: 国外医学(创伤与外科基本问题分册)
• 发表日期: 1999年04期
• 关键词: 绝经后骨质疏松 Alendronate Etidronate 骨密度 二磷酸 治疗作用 间隙性 髋部 骨质疏松症治疗 骨吸收

绝经后骨质疏松患者中约有20％对间隙性etidronate(1-羟基二磷酸钠)治疗无反应。本研究旨在探讨alendronate(4-氨基-1-羟基二磷酸钠)对间隙性etidronate治疗无反应(脊柱骨密度无增加)患者的治疗作用。25

About 20% of postmenopausal osteoporosis patients have no response to intermittent etidronate (sodium 1-hydroxy diphosphate) treatment. This study was designed to investigate the therapeutic effect of alendronate (4-amino-1-hydroxydiphosphate) in patients who have no response to intermittent etidronate therapy (no increase in bone mineral density). 25