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目的:探讨丙氨酰谷氨酰胺(Ala-Gln)对机械通气极低出生体质量儿是否具有肺、肠的保护作用和免疫调节作用。方法:回顾性分析2013年1-12月我院治疗痊愈出院的39例机械通气极低出生体质量儿的临床资料,其中使用Ala-Gln 24例(Ala-Gln组),未使用Ala-Gln 15例(对照组)。比较分析两组患儿在撤机时间、开奶时间、到达正常奶量时间、平均每日体质量增长以及发生喂养不耐受、胆汁淤积、坏死性小肠结肠炎的差异性,并观察Ala-Gln组有无明显不良反应发生。结果:与对照组相比,Ala-Gln组撤机时间、开奶时间、到达正常奶量时间明显缩短,体质量增长快,喂养不耐受、胆汁淤积、坏死性小肠结肠炎发生率明显降低(P均<0.01)。Ala-Gln治疗过程中未见明显不良反应。结论:Ala-Gln对机械通气极低出生体质量儿可能具有肺、肠保护作用和免疫调节作用。
Objective: To investigate whether Ala-Gln can protect lung and intestine and immunoregulatory effects of low birth weight children with mechanical ventilation. Methods: The clinical data of 39 children with mechanically ventilated and very low birth weight who were cured and discharged from January 2013 to January 2013 in our hospital were analyzed retrospectively. Of them, Ala-Gln was used in 24 cases (Ala-Gln group) and Ala-Gln 15 cases (control group). The differences between the two groups in the weaning time, the time of opening milk, the time of reaching the normal milk amount, the average daily body mass gain, the feeding intolerance, cholestasis and necrotizing enterocolitis were compared. The levels of Ala- Gln group had no obvious adverse reactions. Results: Compared with the control group, the Ala-Gln group significantly decreased the weaning time, the opening time, the time to normal milk amount, the rapid growth of body weight, the feeding intolerance, the incidence of cholestasis and necrotizing enterocolitis (P <0.01). Ala-Gln treatment showed no significant adverse reactions. Conclusion: Ala-Gln may have lung and intestinal protective effects and immunomodulatory effects on low birth weight children with mechanical ventilation.