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目的探讨盐城地区女性人乳头瘤病毒感染的年龄特点及亚型分布。方法采用荧光PCR技术,以2187名在妇科门诊或妇女保健科自愿做人乳头瘤病毒感染(HPV)筛查的妇女为研究对象,取其宫颈脱落细胞进行HPV基因分型检测。结果 2187名妇女HPV的总感染率为21.67%(474/2187),高危型感染率为20.16%(441/2187),高危型中单一感染率为16.37%(358/2187),多重感染率为3.80%(83/2187)。各年龄组间HPV总阳性检出率差异无统计学意义(P>0.05),各年龄组间高危型多重感染阳性检出率差异有统计学意义(P<0.05)。结论盐城地区HPV流行的亚型与其他地区相比有明显的差异,而且年龄是影响HPV感染的重要因素之一。
Objective To investigate the age characteristics and subtype distribution of female human papillomavirus (HPV) infection in Yancheng area. Methods A total of 2187 women who were screened for human papillomavirus (HPV) in gynecology clinic or women’s health department were enrolled in this study. Fluorescent PCR was used to detect HPV genotypes in cervical exfoliated cells. Results The total infection rate of HPV was 21.67% (474/2187) in 2187 women, 20.16% (441/2187) in high risk type, 16.37% (358/2187) in high risk type and multiple infection rate was 3.80% (83/2187). There was no significant difference in the positive rate of HPV among all age groups (P> 0.05). The positive rate of high-risk multiple infection among all age groups was significantly different (P <0.05). Conclusion The epidemic subtype of HPV in Yancheng area is obviously different from other regions, and age is one of the important factors affecting HPV infection.