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目的观察基质细胞衍生因子-1(SDF-1)在肝细胞肝癌(HCC)中的表达,探讨SDF-1和HCC的临床、病理特点及术后复发的关系。方法应用免疫组织化学技术检测SDF-1在41例HCC癌组织、癌旁组织和11例正常肝组织中的表达;分析临床、病理资料,并对上述患者进行随访,根据HCC患者术后复发时间进行生存分析。结果 SDF-1在HCC癌组织、癌旁组织及正常肝组织中的表达阳性率分别为68.29%、46.34%、和18.18%(P<0.01)。SDF-1表达强度与肿瘤病理分级呈正相关(低分化为66.67%,高分化为43.48%;转移组为52%,未转移组31.25%),差异有统计学意义(P<0.05)。SDF-1表达阳性、阴性患者12月内的复发率分别为48.1%和14.3%(P<0.01)。结论 SDF-1在HCC中表达上调,SDF-1的高表达在肝癌发生过程中发挥重要作用。SDF-1可作为一种新的判断HCC患者术后复发和预后的指标。
Objective To observe the expression of stromal cell-derived factor-1 (SDF-1) in hepatocellular carcinoma (HCC) and to explore the relationship between SDF-1 and HCC in clinical and pathological features and postoperative recurrence. Methods Immunohistochemistry was used to detect the expression of SDF-1 in 41 cases of HCC, adjacent non-cancerous tissues and 11 cases of normal liver tissues. The clinical and pathological data were analyzed and the patients were followed up. According to the recurrence time of HCC Survival analysis. Results The positive rates of SDF-1 expression in HCC tissues, adjacent non-cancerous tissues and normal liver tissues were 68.29%, 46.34% and 18.18%, respectively (P <0.01). The expression of SDF-1 was positively correlated with tumor grade (66.67% in poorly differentiated group, 43.48% in well differentiated group, 52% in metastatic group and 31.25% in non-metastatic group), the difference was statistically significant (P <0.05). The recurrence rates of SDF-1 positive and negative patients in December were 48.1% and 14.3% (P <0.01), respectively. Conclusions SDF-1 is up-regulated in HCC and high expression of SDF-1 plays an important role in the development of HCC. SDF-1 can be used as a new indicator of postoperative recurrence and prognosis in patients with HCC.