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目的:探讨血清孕酮、人绒毛膜促性腺激素(HCG)及癌抗原125(CA125)水平在宫外孕诊断中的临床应用价值。方法:选择我院妇产科收治的61例宫外孕患者作为观察组,同期选择正常早孕孕妇35例作为对照组,检测并对比两组血清孕酮、β-HCG 48h内增长率及CA125水平,研究三项指标分别检测和联合检测对宫外孕诊断的特异性、敏感性。结果:观察组血清孕酮、β-HCG48 h增长率及CA125检测水平均显著低于对照组,比较差异有统计学意义(P<0.05);单独应用时CA125对于宫外孕具有较高的特异性,而β-HCG 48 h内增长率具有较高的敏感性,三项指标联合检测特异性及敏感性均显著优于单一指标,比较差异具有统计学意义(P<0.05)。结论:血清孕酮、β-HCG及CA125指标水平的分别检测或联合检测,对宫外孕的诊断均有一定的临床价值,而三项指标的联合检测显著优于单一指标。
Objective: To investigate the clinical value of serum progesterone, human chorionic gonadotropin (HCG) and cancer antigen 125 (CA125) in the diagnosis of ectopic pregnancy. Methods: 61 cases of ectopic pregnancy treated by obstetrics and gynecology department of our hospital were selected as observation group. 35 pregnant women with normal early pregnancy were selected as control group during the same period. The serum progesterone and β-HCG in 48 h and CA125 levels were detected and compared Three indicators were detected and combined detection of ectopic pregnancy diagnosis of specificity and sensitivity. Results: The serum progesterone, β-HCG 48 h growth rate and the level of CA125 in the observation group were significantly lower than those in the control group (P <0.05). When used alone, CA125 had high specificity for ectopic pregnancy, However, the rate of increase of β-HCG within 48 h was highly sensitive. The specificity and sensitivity of combined detection of three indexes were significantly better than those of single index. The difference was statistically significant (P <0.05). Conclusion: The detection of serum progesterone, β-HCG and CA125 levels or the combined detection of them all have certain clinical value in the diagnosis of ectopic pregnancy, and the combined detection of three indexes is significantly better than single indicators.