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目的观察自体造血干细胞移植治疗多发性骨髓瘤(multiple myeloma,MM)的临床效果。方法选择2012年1月—2013年12月进行自体外周血造血干细胞移植(autologous peripheral blood hematopoietic stem cell transplantation,APBSCT)治疗的MM患者34例进行临床研究,所有患者均在化疗后进行自体造血干细胞移植治疗,观察患者APBSCT回输后血象恢复情况,观察患者肝功、口腔黏膜炎以及术后感染等并发症的发生情况。结果 APBSCT治疗前CR的10例患者术后均为完全缓解,治疗前部分缓解的22例患者2例完全缓解,1例无效,1例因为重症感染导致死亡。治疗前无效的2例患者1例无效,1例因为重症感染导致死亡。34例行APBSCT治疗的患者发生4例肝功异常、5例腹泻、5例口腔黏膜感染,均经过治疗后好转,发生7例感染中2例重症感染导致患者死亡,5例感染较轻,经抗生素治疗好转。术后并发症发生率总计61.76%。结论使用自体造血干细胞移植对多发性骨髓瘤治疗具有良好的临床疗效,且安全性高,耐受性好,可以尝试在临床中推广应用。
Objective To observe the clinical effect of autologous hematopoietic stem cell transplantation in the treatment of multiple myeloma (MM). Methods Thirty-four patients with MM who underwent autologous peripheral blood hematopoietic stem cell transplantation (APBSCT) from January 2012 to December 2013 were enrolled in this study. All patients underwent chemotherapy with autologous hematopoietic stem cell transplantation After treatment, the recovery of APBSCT blood was observed and the complications such as liver function, oral mucositis and postoperative infection were observed. Results All 10 CR patients treated with APBSCT were completely relieved postoperatively. Two of 22 patients who were partially relieved before treatment were completely relieved. One patient was ineffective and one patient died of severe infection. One patient was ineffective in 2 patients before treatment and one patient died due to severe infection. Among the 34 patients who underwent APBSCT, 4 cases of abnormal liver function, 5 cases of diarrhea and 5 cases of oral mucosal infection occurred. All of them were improved after treatment. Two of the seven cases of severe infection caused the death of the patients, and five cases of infection were mild. Antibiotic treatment improved. The incidence of postoperative complications was 61.76%. Conclusion Autologous hematopoietic stem cell transplantation for the treatment of multiple myeloma has good clinical efficacy, and high safety, good tolerance, you can try to promote the clinical application.