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目的:测定新喹诺酮YH-6对支原体的抑制活性并与其它抗微生物药剂作比较。方法:MIC的测定采用微量稀释法。结果:YH-6对解脲支原体(Uu),人型支原体(Mh),口腔支原体(Mo),唾液支原体(Ms)的MIC分别为250μg·L~(-1),500μg·L~(-1),125μg·L~(-1),125μg·L~(-1),它的抑制活性与红霉素,柱晶白霉素相当,是氧氟沙星的2-8倍。Uu,Mh对YH-6及交沙霉素和泰洛星不易产生诱导耐药性,而对红霉素和四环素易产生诱导耐药性和多重耐药性,而对YH-6,交沙霉素和泰洛星无多重耐药性。结论:YH-6对支原体有很强的抑制活性,且不易形成诱导耐药性。Uu和Mh的红霉素或四环素抗性菌株对YH-6无多重耐药性。
OBJECTIVE: To determine the inhibitory activity of neoquinolone YH-6 against mycoplasma and to compare with other antimicrobial agents. Methods: The determination of MIC using microdilution method. Results: The MICs of YH-6 to Uu, Mh, M and Ms were 250μg · L -1, 500μg · L -1, 1), 125μg · L -1, 125μg · L -1. The inhibitory activity was equivalent to erythromycin and leucomycin, and was 2-8 times of that of ofloxacin. Uu and Mh are not easy to induce drug resistance to YH-6, josamycin and tylosin, while erythromycin and tetracycline are easy to induce drug resistance and multi-drug resistance. However, YH-6, No multi-drug resistance to tamoxifen and tylosin. Conclusion: YH-6 has a strong inhibitory activity against Mycoplasma and is not easy to induce drug resistance. Erythromycin or tetracycline resistant strains of Uu and Mh were not multi-resistant to YH-6.