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可引起成人呼吸窘迫综合征(Adult Respiratory Distress Syndrome,ARDS)的原因是多方面的,始动机制不完全一样,但总的说来,ARDS的发生和发展是肺微循环障碍,毛细血管-肺泡膜受损和肺泡表面活性物质缺失的结果。 肺泡表面活性物质(Pulmonary Surfactant,PS)系统的变化与肺部疾病的关系日愈受到重视。Avery等(1959)发现患呼吸窘迫综合征新生儿的肺浸出液表面张力增加是肺泡表面披复物变化的结果;Tyler(1964)和Kikkawa(1965)先后用电镜显示出肺泡表面活性层和肺泡上皮细胞内嗜锇酸包含体变化与新生儿呼吸窘迫综征发生的关系,揭示了PS系
The causes of Adult Respiratory Distress Syndrome (ARDS) are manifold and the mechanism of initiation is not exactly the same. However, in general, the occurrence and development of ARDS are pulmonary microcirculation disorder, capillary-alveolar Membrane damage and loss of alveolar surfactant results. Pulmonary Surfactant (Pulmonary Surfactant, PS) system changes and the relationship between lung disease more and more attention. Avery et al. (1959) found that increased surface tension of lung extracts from neonates with respiratory distress syndrome was the result of changes in the fabric on the surface of the alveoli; Tyler (1964) and Kikkawa (1965) had electron microscopic images of alveolar surface active layer and alveolar epithelium The relationship between changes of intracellular osmolar acid inclusion bodies and neonatal respiratory distress syndrome revealed that PS