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目的 探讨 HL A- DR多态性与 SLE的易感性关系。方法 用聚合酶链反应 -序列特异引物 (PCR- SSP)方法 ,对 80例 SLE患者和 1 0 4例健康人 HLA- DR基因进行研究。结果 SL E患者 DR1 5基因频率明显升高 (P<0 .0 0 1 ,RR=3.86) ,DR3、 DR4基因频率显著下降 (P<0 .0 5,RR=0 .48;P<0 .0 5,RR=0 .38) ,DR1 5阳性的患者中狼疮性肾炎发病率高于其它患者 (P<0 .0 5,RR=3.1 5) ,抗 SSA抗体也明显升高 (P<0 .0 5,RR=3.46)
Objective To investigate the relationship between HL-DR polymorphism and susceptibility to SLE. Methods The HLA-DR gene of 80 SLE patients and 104 healthy subjects were studied by polymerase chain reaction-sequence-specific primers (PCR-SSP). Results The frequency of DR1 5 gene was significantly higher in patients with SL E (P <0.01, RR = 3.86), and the frequencies of DR3 and DR4 genes were significantly decreased (P <0.05, RR = 0.48; 0 5, RR = 0.38). The incidence of lupus nephritis in DR1 5 positive patients was higher than that in other patients (P <0.05, RR = 3.1 5) .0 5, RR = 3.46)