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测定卵巢组织标本中抗原的含量.方法:对33份卵巢组织标本用放射性碘标记单克隆抗体MoV18进行定量放射自显影测定.其中22份为卵巢癌,7份为卵巢良性肿瘤,4份为正常卵巢组织.结果:19份浆液性卵巢癌中,17份有CA-MoV18抗原表达,含量为1.30~59.28pmol/g组织.3份粘液性卵巢癌及11份非恶性卵巢组织中(7份良性病变,4份正常组织)未测得CA-MoV18抗原.结论:CA-MoV18抗原在浆液性卵巢癌中有表达,其含量与肿瘤组织中标记抗体含量(%ID/g)有关.关键词
Determination of ovarian tissue antigen content. Methods: Quantitative autoradiography was performed on 33 ovarian tissue specimens with radioactive iodine labeled monoclonal antibody MoV18. Among them, 22 were ovarian cancer, 7 were benign ovarian tumors and 4 were normal ovarian tissues. RESULTS: Of the 19 serous ovarian cancers, 17 had CA-MoV18 antigen expression levels ranging from 1.30 to 59.28 pmol / g tissue. CA-MoV18 antigen was not detected in 3 mucinous ovarian carcinomas and in 11 non-malignant ovarian tissues (7 benign lesions, 4 normal tissues). Conclusion: CA-MoV18 antigen is expressed in serous ovarian cancer and its content is related to the content of labeled antibody in tumor tissue (% ID / g). Key words