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目的通过临床、细胞形态学、细胞化学染色及分子生物学的检测对１例疑难病人进行诊断及鉴别诊断。方法运用细胞形态学、细胞化学染色及分子遗传学检测指标与临床相结合进行检查与分析。结果确诊１例罕见的Ｐｈ－／ｂｃｒ＋ＣＭＬ早期慢性期－红血病兼患淋巴瘤。结论该病例为十分罕见的多能干细胞克隆恶性增生疾病的多重癌罹患。其细胞形态学及分子生物学发现对诊断与鉴别诊断起了重要作用。
Objective To diagnose and differentially diagnose a difficult patient by clinical, cytomorphological, cytochemical staining and molecular biology. Methods The combination of cell morphology, cytochemical staining and molecular genetic testing indicators with the clinical examination and analysis. The results confirmed a rare case of Ph-/bcr+CML in the early stage of chronic-erythrocytic disease and lymphoma. Conclusion This case is a rare case of pluripotent stem cells that colonize multiple cancers of malignant proliferation. The discovery of cell morphology and molecular biology plays an important role in diagnosis and differential diagnosis.