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目的：研究乙型肝炎病毒基因重组（ＣＨＯ）疫茵对ＨＢｓＡｇ和ＨＢｅＡｇ双阳性母亲所生婴儿的阻断效果。方法：选７０例生于母亲为ＨＢｓＡｇ和ＨＢｓＡｇ双阳性的婴儿，随机分为Ａ组（３１例）和Ｂ组（３９例）。Ａ组为单纯疫苗组，注射３次疫苗（０．ｌ、６月， １０μｇ／次）；Ｂ组为疫苗加乙肝免疫球蛋自（ＨＢＩＧ）组，注射３次疫苗（同Ａ组），并于出生时注射半支（５０ＩＵ）ＨＢＩＧ。全程２～６个月采血，用固相放射免疫（ＲＩＡ）法检测抗－ＨＢｓ、ＨＢｓＡｇ和抗－ＨＢｃ。结果：抗抗－ＨＢｓ阳转率为 ８３．８７％，阻断率为８３．８７％，疫苗加半量乙肝免疫球蛋白（５０ ＩＵ）组分别为９３．１０％和９３．５９％。 结论：乙肝基因重组（ＣＨＯ）疫苗有良好的阻断乙肝母婴传播的效果，如果出生时加注半支ＨＢＩＧ效果更好。
Objective: To study the blocking effect of hepatitis B virus (HBV) gene recombination (CHO) on infants born to HBsAg and HBeAg-positive mothers. Methods: Totally 70 infants born to mothers with double positive HBsAg and HBsAg were randomly divided into group A (n = 31) and group B (n = 39). Group A was a vaccine group with 3 vaccinations (0.1, 6 and 10 μg / time); Group B was vaccinated with HBIG and injected with 3 vaccines (group A) Half-birth (50IU) HBIG was injected at birth. The whole blood was collected for 2 to 6 months, and anti-HBs, HBsAg and anti-HBc were detected by radioimmunoassay (RIA). Results: The anti-HBs positive rate was 83.87% and the blocking rate was 83.87%. The vaccine plus half dose of hepatitis B immunoglobulin (50 IU) was 93.10% and 93.59% respectively. Conclusion: The hepatitis B gene recombinant (CHO) vaccine has a good effect of blocking mother-to-child transmission of hepatitis B, and it is better to add HBIG at birth.