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高渗氨比钠溶液（ＨＳ）时低容量性休克有显著的复苏效果，但其缺点之一是加剧术中出血。本文通过给一组择期手术病人术前输入７．５％氯化钠溶液５ｍｌ／ｋｇ，观察输注前和输注后３０ｍｉｎ下述指标的变化探讨其原因：血小板计数、纤维蛋白原含量、白陶土部分凝血活酶时间、ＦＶⅢ：Ｃ、ＦＶⅢＲ：Ａｇ、优球蛋白凝块溶解时间、组织纤溶酶原激话物以及纤溶酶原激活物灭活物活性。结果：（１）内凝血途径未被激活；（２）血小板和纤维蛋白原含量无消耗性减少；（３）内皮细胞受到高渗氯化钠的刺激后，ＦＶⅢＲ：Ａｇ未受影响；但是（４）组织纤溶酶原激活物活性增加，而纤溶酶原激活物灭活物活性下降。上述结果说明了有原发性纤溶存在，可能是输注ＨＳ后造成出血的原因之一。尚有许多问题有待深入研究。
Hypertonic ammonia than sodium solution (HS) low-capacity shock has a significant recovery effect, but one of its shortcomings is to exacerbate intraoperative bleeding. In this paper, a group of elective surgery patients preoperative input of 7.5% sodium chloride solution 5ml / kg, before and after infusion observed changes in the following indicators 30min explore its causes: platelet count, fibrinogen content, white Clay partial thromboplastin time, FVIII: C, FVIIIR: Ag, euglobulin clot lysis time, tissue plasminogen activator and plasminogen activator inactivator activity. Results: (1) The coagulation pathway was not activated; (2) the platelet and fibrinogen content were not decreased; (3) FVIIIR: Ag was not affected by hypertonic sodium chloride stimulation in endothelial cells; 4) Tissue plasminogen activator activity increases, while plasminogen activator inactivator activity decreases. The above results illustrate the presence of primary fibrinolysis, which may be one of the causes of bleeding after HS infusion. There are still many problems to be studied in depth.