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许多合并卡氏肺囊虫肺炎的艾滋病(AIDS)患者,在接受复方新诺明治疗时出现了药物性皮肤反应.本文报道1例尽管有皮肤反应但还是成功地继续使用了该药治疗.患者男,45岁,诊断为AIDS.患者衰弱、恶心、发热及干咳已4周.X线显示两肺浸润.临床诊断为卡氏肺囊虫肺炎,用大剂量的复方新诺明(甲氧苄胺嘧啶1120mg/d,磺胺甲基异恶唑5600mg/d)治疗.48小时内体温恢复正常,肺部浸润消失.第10天患者出现发热,并伴有泛发性进行性红色斑丘疹.开始服扑尔敏2mg,每日3次,并继续用复方新诺明治疗.热度及皮疹逐渐消退.患者完成了疗程,而未出现进一步的不良反应出院后数月仍预防性地服用复方新诺明AIDS患者使用复方新诺明治疗时,原因不明
Many AIDS patients with Pneumocystis carinii pneumonia developed a drug-induced skin reaction when receiving cotrimoxazole and one was reported to continue the drug despite successful skin reactions. Male, 45 years old, diagnosed as AIDS. Patients with weakness, nausea, fever and dry cough for 4 weeks .X ray showed pulmonary infiltrates .Pneumocystis carinii pneumonia was diagnosed clinically, with high-dose cotrimoxazole Amine pyrimidine 1120mg / d, sulfamethoxazole 5600mg / d) treatment .48 hours returned to normal body temperature, lung infiltration disappeared .10 days patients with fever, accompanied by generalized red rash. Serum chlorpheniramine 2mg, 3 times a day, and continue with cotrimoxazole treatment. Heat and rash gradually subsided. Patients completed the course of treatment, and no further adverse reactions were still prophylactic taking compound nocturnine for several months after discharge Unknown AIDS patients using cotrimoxazole treatment, the reason is unknown