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气道反应性亢进(hyperreactivity)是指气管一支气管树对物理、化学及药物等非抗原性刺激的过度反应性。自从1921年 Al-exander 等首次发现注射匹罗卡品可使哮喘病人呈现持续性呼气困难以来,众多研究已证明;组织胺、5-羟色胺、缓激肽、前列腺素F_2α口以及乙酰胆碱、乙酰甲胆碱、碳酰胆硷等胆碱能制剂均可使气道反应性亢进者发生支气管痉挛;运动、过度通气,吸入干冷空气、粉尘等刺激亦可使气道反应性亢进者形成哮喘发作。气道反应性亢进是哮喘的主要特征之一
Hyperreactivity refers to the overreactivity of a tracheobronchial tree to non-antigenic stimuli, such as physical, chemical and pharmaceutical reactions. Many studies have shown that histamine, serotonin, bradykinin, prostaglandin F_2α, as well as acetylcholine, acetylcysteine, and acetylcholine have been found in asthmatics since the first discovery by pilots such as Al-exander in 1921, Choline, carbachol and other cholinergic agents can make airway hyperresponsiveness to bronchospasm; exercise, hyperventilation, inhalation of dry air, dust and other stimuli can also make airway hyperresponsiveness asthma attack . Airway hyperresponsiveness is one of the main characteristics of asthma