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目的:观察脑出血(CH)、脑梗死(CI)患者血清、一氧化氮(NO)、一氧化氮合酶(NOS)、丙二醛(MDA)、超氧化物歧化酶(SOD)、维生素C(VitC)、维生素E(VitE)的水平动态变化及其临床意义。方法:选择急性脑血管病(ACVD)患者114例,其中CI组65例,CH组49例。通过生物化学方法检测血清NO、NOS、MDA、SOD、VitE、VitC含量并与对照组进行对照。结果:CI组、CH组NO、NOS、MDA水平显著高于对照组(P<0.01),于发病后1周内显著升高,2周或3周开始下降;SOD、VitE、VitC水平显著低于对照组(P<0.01),于发病后1周内显著降低。结论:ACVD患者NO、NOS、MDA早期含量明显升高,参与了ACVD脑组织损伤的病重过程。
Objective: To observe the changes of serum, nitric oxide (NO), nitric oxide synthase (NOS), malondialdehyde (MDA), superoxide dismutase (SOD) and vitamins in patients with cerebral hemorrhage (CH) C (VitC), Vitamin E (VitE) levels and their clinical significance. Methods: A total of 114 patients with acute cerebrovascular disease (ACVD) were selected, including 65 cases in CI group and 49 cases in CH group. The contents of NO, NOS, MDA, SOD, VitE and VitC in serum were detected by biochemical methods and compared with the control group. Results: The levels of NO, NOS and MDA in CI group and CH group were significantly higher than those in control group (P <0.01), and were significantly increased in 1 week and decreased in 2 weeks or 3 weeks. The levels of SOD, VitE and VitC were significantly lower In the control group (P <0.01), significantly reduced within 1 week after onset. CONCLUSION: The early stage of NO, NOS and MDA in ACVD patients is significantly increased, which is involved in the pathogenesis of ACVD brain injury.