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不少研究报道证实,即使临床症状轻微的哮喘患者,其气道也存在炎症过程。临床短程应用皮质类固醇吸入对哮喘患者的症状减轻和气道反应性的降低极为有效。β_2-激动剂目前已被列为减轻支气管缩窄的首选药物之一,但有人报道长期应用短效β_2-激动剂不能降低气道反应性,甚至会使症状恶化。为此进行随机双盲多中心研究,探讨常规支气管扩张药加皮质类固醇吸入,治疗儿童哮喘的远期疗效,并与单纯常规支气管扩张药治疗进行比较。
Many studies have confirmed that, even if the clinical symptoms of mild asthma patients, the airway also exists the inflammatory process. Clinical short-term use of corticosteroid inhalation is particularly effective in reducing symptoms and reducing airway responsiveness in asthmatics. Beta 2-agonists are currently listed as one of the first drugs to reduce bronchoconstriction. However, long-term use of short-acting beta-2-agonists has been reported to not reduce airway responsiveness and even worsen symptoms. To do this randomized double-blind multicenter study to explore the long-term efficacy of conventional bronchodilator plus corticosteroid inhalation in the treatment of childhood asthma and compared with conventional bronchodilator treatment.