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目的探究中性粒细胞/淋巴细胞比值(NLR)、超敏C反应蛋白(hs-CRP)、血小板平均体积(MPV)与肥胖、非肥胖型多囊卵巢综合征(PCOS)的关系。方法对112例PCOS患者(肥胖型68例,非肥胖型44例)和年龄、BMI配对的90例健康体检女性(健康对照组肥胖型47例,非肥胖型43例),检测并比较两组及亚组之间MPV、NLR、hs-CRP、生殖内分泌激素及代谢指标。结果PCOS组血清空腹血糖水平(FPG)、空腹胰岛素(FINS)、稳态胰岛素评价指数(HOMA-IR)、NLR、hs-CRP、MPV水平均明显高于健康对照组(均P<0.05)。肥胖型PCOS组NLR、hs-CRP、MPV高于肥胖型健康对照组(均P<0.05)。肥胖型PCOS组NLR、hs-CRP、MPV均高于非肥胖型PCOS组(均P<0.05)。NLR、hs-CRP、MPV的AUC及95%CI分别为0.819(0.763~0.903)、0.982(0.959~1.000)、0.906(0.848~965)。结论肥胖型PCOS患者血清NLR、hs-CRP、MPV水平明显升高,这些指标的变化对肥胖型PCOS代谢异常有较强的诊断价值。
Objective To investigate the relationship between neutrophil / lymphocyte ratio (NLR), hs-CRP, MPV and obesity, non-obese polycystic ovary syndrome (PCOS). Methods A total of 112 healthy women with PCOS (obese 68 cases, non-obese 44 cases) and age and BMI were enrolled in this study. The healthy controls were divided into two groups: obese 47 cases and non-obese 43 cases And subgroup of MPV, NLR, hs-CRP, reproductive hormones and metabolic indicators. Results Serum levels of fasting plasma glucose (FPG), fasting insulin (FINS), homeostasis insulin assessment index (HOMA-IR), NLR, hs-CRP and MPV in PCOS group were significantly higher than those in healthy control group (all P <0.05). The levels of NLR, hs-CRP and MPV in obese PCOS group were higher than those in obese healthy group (all P <0.05). The obese PCOS group had higher NLR, hs-CRP and MPV than non-obese PCOS group (all P <0.05). The AUC and 95% CI of NLR, hs-CRP and MPV were 0.819 (0.763-0.903), 0.982 (0.959-1.000) and 0.906 (0.848-965), respectively. Conclusions Serum levels of NLR, hs-CRP and MPV in obese patients with PCOS are significantly increased. The changes of these indexes have a strong diagnostic value in obesity PCOS.