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本文测定分析了50例Duchenne型肌营养不良症(DMD)患者及97名正常男性对照组的血清肌酸激酶(CK)、肌酸激酶MB同功酶(CK-MB)、乳酸脱氢酶(LDH)、丙酮酸激酶(PK)、肌红蛋白(mb)。结果:CK、PK、mb50例均异常升高,CK-MB、LDH48例升高;患者年龄、病程、肢体功能均与五项生化指标呈负相关,而年龄、病程、肢体功能之间存在正相关。提示:在诊断DMD中,PK、mb与CK具有同等价值,CK-MB、LDH稍次;各项指标在病程早期的诊断更具特征性。
In this study, 50 patients with Duchenne muscular dystrophy (DMD) and 97 normal male controls were analyzed for serum creatine kinase (CK), creatine kinase MB isoenzyme (CK-MB), lactate dehydrogenase LDH), pyruvate kinase (PK), myoglobin (mb). Results: CK, PK, mb50 cases were abnormally elevated, CK-MB, LDH48 cases increased; patient age, disease duration, limb function and biochemical indicators were negatively correlated with age, disease duration, limb function exists between positive Related. Tip: in the diagnosis of DMD, PK, mb and CK have the same value, CK-MB, LDH slightly; the indicators in the early diagnosis of the disease is more characteristic.