论文部分内容阅读
目的观察右佐匹克隆治疗吸毒史合并睡眠障碍患者的临床疗效及安全性。方法将80例吸毒史合并睡眠障碍患者随机分为治疗组和对照组各40例。对照组采用地西泮片治疗,治疗组采用右佐匹克隆胶囊治疗,对比2组的临床疗效、睡眠质量改善情况及不良反应发生率。结果治疗组的治疗总有效率为87.50%,对照组的治疗总有效率为80.00%,2组总有效率比较差异无统计学意义(P>0.05)。治疗前2组的匹兹堡睡眠质量指数量表评分比较无显著差异(P>0.05),治疗后2组患者的匹兹堡睡眠质量指数量表评分均低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05)。治疗组的不良反应发生率为12.50%(5/40)低于对照组的25.00%(10/40),差异有统计学意义(P<0.05)。结论吸毒史合并睡眠障碍患者采用右佐匹克隆治疗后,用药疗效好,不良反应发生率低,同时显著改善患者的睡眠质量,用药安全性与有效性更高。
Objective To observe the clinical efficacy and safety of dezopiclone in the treatment of drug abuse history patients with sleep disorders. Methods 80 cases of drug abuse history with sleep disorders were randomly divided into treatment group and control group of 40 cases. The control group was treated with diazepam, and the treatment group was treated with dexrazoxane. The clinical curative effect, the improvement of sleep quality and the incidence of adverse reactions were compared between the two groups. Results The total effective rate was 87.50% in the treatment group and 80.00% in the control group. There was no significant difference in the total effective rate between the two groups (P> 0.05). There was no significant difference in the Pittsburgh Sleep Quality Index Scale between the two groups before treatment (P> 0.05). After treatment, the Pittsburgh Sleep Quality Index Scale scores of two groups were lower than before treatment, and the treatment group was lower than the control group, the difference All were statistically significant (P <0.05). The incidence of adverse reactions in the treatment group was 12.50% (5/40), which was lower than that in the control group (25.00%, 10/40). The difference was statistically significant (P <0.05). Conclusion In the drug abuse history with dexrazoxane in patients with sleep disorders, the medication is effective and the incidence of adverse reactions is low. At the same time, the patients’ sleep quality is significantly improved, and the medication safety and effectiveness are higher.