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目的探讨妊娠高血压综合征(妊高征)患者血清瘦素含量的变化及其在妊高征发病中的意义。方法采用放射免疫分析法(R IA)测定50例妊高征患者(HDP组,其中妊娠期高血压组12例,轻度子痫前期组20例,重度子痫前期组18例)、50例正常晚孕妇女(对照组)患者血清瘦素。结果 HDP组的血清瘦素值(24.23±7.94)μg/L显著高于对照组(10.12±3.15)μg/L(P<0.001),以子痫前期组增高明显。结论血清瘦素水平与妊高征的发生和病情程度有关。
Objective To investigate the changes of serum leptin in patients with pregnancy induced hypertension (PIH) and its significance in the pathogenesis of pregnancy induced hypertension. Methods Fifty cases of PIH (HDP group, 12 cases of gestational hypertension group, 20 cases of mild preeclampsia group, 18 cases of severe preeclampsia group) and 50 cases of severe preeclampsia were detected by radioimmunoassay (RIA) Normal pregnant women (control group) patients with serum leptin. Results The serum leptin level of HDP group was significantly higher than that of control group (10.12 ± 3.15) μg / L (P <0.001) (24.23 ± 7.94) μg / L and significantly higher in preeclampsia group. Conclusions Serum leptin level is related to the occurrence and severity of PIH.