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乳糖酶微囊作为一种口服药剂可用于缺乏乳糖酶的人,临床剂量为成人每日500~1000单位(即一颗约0.3克)可以防止因饮奶而产生的消化道不适。为探讨其是否具有胚胎毒性或致畸性,我们对此进行了大白鼠致畸性研究,现将试验结果报告如下。材料和方法1．材料:受试样品为乳糖酶微囊,由浙江医科大学生化教研室提供,试验前用PBS液配成试验所需浓度。实验动物:由上海中科院实验动物中心提供的SD种大鼠,雌鼠体重170~210克,雄鼠体重为230~250克,饲料按标准基础饲料配方。
Lactase microcapsules as an oral agent can be used in lactose-deficient humans at doses of 500-1000 units daily (ie, about 0.3 grams) per adult to prevent digestive upset due to drinking milk. To investigate whether it has embryotoxicity or teratogenicity, we conducted a teratogenic study of rats, the test results are reported below. Materials and methods 1. MATERIALS: The tested samples were lactase microcapsules, which were provided by Department of Biochemistry, Zhejiang Medical University. Before the test, they were dosed with PBS solution to the concentration required for the test. Experimental animals: The SD rats provided by the Laboratory Animal Center of Shanghai Chinese Academy of Sciences have female body weight of 170-210 g and male body weight of 230-250 g. The feed is formulated according to the standard basic diet.