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人血浆脂蛋白相关磷脂酶A2(Lp-PLA2)又称血小板活化因子乙酰水解酶(PAF-AH),主要由巨噬细胞合成和分泌。大部分Lp-PLA2与低密度脂蛋白结合,能水解灭活血小板活化因子,水解低密度脂蛋白上的氧化磷脂,生成溶血卵磷脂和氧化型游离脂肪酸,因此既有抗炎抗动脉粥样硬化,又有促炎促动脉粥样硬化的作用。近年来,越来越多的研究表明,Lp-PLA2具有促动脉粥样硬化作用,是心血管病的风险预测因子,可能成为心血管病新的治疗目标。
Human plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating factor acetylhydrolase (PAF-AH), is synthesized and secreted by macrophages. Most of Lp-PLA2 binds to low density lipoprotein, which can hydrolyze and inactivate platelet activating factor, hydrolyze oxidized phospholipid on low density lipoprotein, generate lysophosphatidylcholine and oxidized free fatty acid, so that both anti-inflammatory anti-atherosclerotic , But also pro-inflammatory pro-atherosclerosis role. In recent years, more and more studies have shown that Lp-PLA2 has a role in promoting atherosclerosis and is a risk predictor of cardiovascular disease and may be a new therapeutic target for cardiovascular disease.