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To study the rational and scientific way of administrating the drugs whose pharmacokinetics conform to three-compartment open model. Based on the double-bottle exponential decay infusion introduced by Sun Rui-yuan and Song Jian-guo, this manuscript describe the combined multi-bottle exponential decay infusion(CMI) in achieving optimal plasma drug concentration that ensure adequate therapeutic effects in the absence of significant side effects and a rapid return of recovery. Laplace’s transformation was applied to verify group of equations listed according to the specific apparatus and the three compartments with elimination occurs mainly through central compartment, which yields the following equations used in calculating the volumes and concentration of bottle A, B and P respectively: Ca=CssV1K10d;Cbo=CadK31αβ(α+β-K31);Vb=dK31;Cpo=CaπK10;Vp=dK21;C1(t)=dCaK10V1(1-eπt). It is estimated that the plasma concentration against time curve of the CMI is the function in mathematics of pai(π), the fast distribution rate constant while in the situation of conventional mono-bottle infusion, the C-T curve is the function in mathematics of beta (β), the slow distribution rate constant. Individual pharmacokinetic parameters were obtained and used for calculating the appropriate volumes and concentrations of each bottle needed. It has verified by animal experiment that the target plasma propofol levels (measured using HPLC) were rapidly attained and maintained as desired, thus provided an alternative method of drug delivery.
To study the rational and scientific way of administrating the drugs that pharmacokinetics conform to three-compartment open model. Based on the double-bottle exponential decay infusion introduced by Sun Rui-yuan and Song Jian-guo, this manuscript describe the combined multi-bottle Laplace’s transformation was applied to verify group of equations according to the specific apparatus and the three compartments Cba = CadK31αβ (α + β-K31); Vb = dK31; Cpo = It is estimated that the plasma concentration against time curve of the CMI is the function in mathematics of pa the fast distribution rate constant while in the situation of conventional mono-bottle infusion, the CT curve is the function in mathematics of beta (β), the slow distribution rate constant. Individual pharmacokinetic parameters were obtained and used for calculating the appropriate volumes and concentrations of each bottle needed. It has verified by animal experiment that the target plasma propofol levels (measured using HPLC) were rapidly attained and maintained as desired, thus provided an alternative method of drug delivery.