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对免疫性血小板减少紫癜(ITP)患儿常规使用或不用类固醇激素治疗,其6个月内完全恢复率为90%,仍有7～10%的患儿转变为慢性过程。对这些患有慢性难治性ITP儿童的治疗仍有争议。迄今,所有药物都来能显示出一致性的疗效,某些药物还表现出严重的副作用。本文用秋水仙碱治疗慢性ITP,经验如下。病例和方法14例患儿,年龄2～10岁(男8,女6)均具有典型ITP临床症状及骨髓象,且症状已持续6～36个月。在本疗法治疗前8例、4例、2例分别用强的松、强的松加VCR(长春新碱)、强的松加达那唑治疗,疗效差。本组秋水仙碱用量为0.1～0.3mg/d,分次口服2～6个月,并隔日服用或不用强的松治疗(1mg/kg)。每4～6周进行一次血小
In children with immune thrombocytopenic purpura (ITP), children with or without steroid treatment have a complete recovery rate of 90% within 6 months and 7 to 10% of children still have chronic disease. The treatment of these children with chronic, refractory ITP is still controversial. To date, all medications have shown consistent efficacy and some have shown serious side effects. Colchicine treatment of chronic ITP in this paper, the experience is as follows. Cases and Methods Fourteen children, aged 2 to 10 years old (male 8 and female 6), had typical ITP clinical symptoms and bone marrow symptoms, and the symptoms persisted for 6 to 36 months. 8 cases in the treatment before treatment, 4 cases, 2 cases were treated with prednisone, prednisone VCR (vincristine), prednisone and danazol treatment, poor efficacy. The group of colchicine dosage of 0.1 ~ 0.3mg / d, oral administration of 2 to 6 months, and the next day or without prednisone treatment (1mg / kg). Blood is taken every 4 to 6 weeks