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系统性红斑狼疮(SLE)是一种多系统的炎症性疾病,神经系统的受累是较突出的。有时其临床表现与其他因素引起的神经精神障碍较难区别,给治疗带来一定的困难。由于在一些神经系统疾病中对神经组织中环核苷酸的研究提示,在它们的代谢和功能中可能涉及到环磷鸟苷(c-GMP)和环磷腺苷(c-AMP),故作者对有神经症状的SLE病人测定脑脊液中c-GMP和c-AMP的含量。结果发现有c-GMP的增高。
Systemic lupus erythematosus (SLE) is a multi-systemic inflammatory disease that is more prominent in the nervous system. Sometimes the clinical manifestations of neuropsychiatric disorders caused by other factors more difficult to distinguish, to bring some difficulties in the treatment. Since studies of cyclic nucleotides in neural tissues in some neurological diseases suggest that cyclosporin (c-GMP) and cyclic adenosine monophosphate (c-AMP) may be involved in their metabolism and function, the authors Cerebral spinal fluid levels of c-GMP and c-AMP were measured in patients with neurological symptoms of SLE. As a result, there was an increase in c-GMP.