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本实验观察川芎嗪对家兔实验性膜性肾炎时血小板功能变化的影响，并探讨血小板功能异常与膜性肾炎病理变化的关系。结果表明：川芎嗪对本型肾炎的发展有较明显的治疗作用。其作用机制可能是通过降低血小板聚集性，抑制血小板ＴＸＡ＿（２）生成和活性，增加血小板ｃＡＭＰ含量，抑制血小板内容物的释放，调节血浆和肾组织ＴＸＡ＿（２）／ＰＧＩ＿（２）的平衡，从而稳定血小板而减轻肾小球基底膜的损伤，阻抑渗出，减轻蛋白尿，从而改善肾功能，减轻肾组织的病理损伤。
This experiment was conducted to observe the effects of tetramethylpyrazine on platelet function in rabbits with experimental membranous nephritis, and to explore the relationship between platelet dysfunction and pathological changes of membranous nephritis. The results showed that: Ligustrazine has obvious therapeutic effect on the development of this type of nephritis. The mechanism of action may be through the reduction of platelet aggregation, inhibition of platelet TXA_(2) production and activity, increase of platelet cAMP content, inhibition of platelet content release, and regulation of plasma and renal tissue TXA_(2)/PGI_(2) balance. So as to stabilize the platelets and reduce the glomerular basement membrane damage, inhibition of exudation, reduce proteinuria, thereby improving renal function, reduce renal pathological damage.