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目的:为有效治疗新生儿缺氧缺血性脑病,临床探究神经节苷脂钠用于治疗的有效性。方法:以2014年6月至2015年6月新兴县妇幼保健院诊断为缺氧缺血性脑病的360例新生儿患儿为研究对象,将患儿分为对照组与治疗组,每组180例。对照组患儿给予对症治疗,治疗组加用神经节苷脂钠,对患儿症状改善情况进行评估,同时对患儿进行新生儿神经行为(NABA)评分。结果:入院时患儿神经行为评分比较,差异无统计学意义(P>0.05),用药治疗3 d、1周、2周治疗组神经行为评分高于对照组,差异具有统计学意义(P<0.05);治疗组症状改善有效率为90.0%,对照组为77.8%,两组比较,差异具有统计学意义(P<0.05)。结论:对于出现缺氧缺血性脑病的新生儿,临床在进行对症治疗时使用神经节苷脂钠,能提高治疗效果、加快患儿症状改善。
Objective: To effectively treat neonatal hypoxic-ischemic encephalopathy, clinical efficacy of ganglioside sodium for the treatment of. Methods: A total of 360 neonates with hypoxic-ischemic encephalopathy diagnosed as HIE in Xinxing County from June 2014 to June 2015 were divided into control group and treatment group example. Children in the control group were given symptomatic treatment. Patients in the treatment group were treated with ganglioside sodium to evaluate their symptoms. Neonatal neurobehavioral (NABA) scores were also evaluated. Results: There was no significant difference in neurobehavioral scores between the two groups (P> 0.05). The scores of neurobehavioral scores in the treatment group at 3 d, 1 week and 2 weeks after treatment were significantly higher than those in the control group (P < 0.05). The effective rate of symptom improvement was 90.0% in the treatment group and 77.8% in the control group, the difference was statistically significant (P <0.05). Conclusion: For newborns with hypoxic ischemic encephalopathy, clinical use of ganglioside in symptomatic treatment can improve the therapeutic effect and speed up the improvement of symptoms in children.