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DNA甲基化转录抑制的机制之一是通过在甲基化 DNA上结合上特异的转录抑制因子 (repressors)发挥作用的 ,这种转录抑制因子即为甲基 Cp G结合蛋白 (Me CP)。现已发现了多种甲基 Cp G结合蛋白 ,如 Me CP1和 Me CP2等 ,本文主要介绍 Me CP2的研究状况及与 Rett综合征的关系
One of the mechanisms by which DNA methylation inhibits transcription is through the binding of methylated DNA to specific transcriptional repressors known as methyl Cp G binding protein (Me CP). Have now found a variety of methyl Cp G binding proteins, such as Me CP1 and Me CP2, etc. This paper describes the research status of Me CP2 and the relationship with Rett syndrome