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印度楝Azadirachta indica在印巴次大陆到处可见,几乎树的每一部分在民间都用来治疗疾病,并已从中分出许多成分,其中某些成分具显著的抗感染、抗风湿、抗溃疡、解热、抗肿瘤及杀虫作用。此文报道新鲜、未粉碎、成熟的果皮在室温下反复用乙醇提取,乙醇浸膏用水-乙酸乙酯分配,乙酸乙酯层经各种溶媒反复处理,结合柱层析、薄层等手段分得了一个新四环三萜化合物azaditol〔1〕,一个从苦楝Melicaagedarach中已分得过的三萜库内酯(kulac-tone)及已知化合物环氧印苦楝二酮(ipoxyazdiradione)。 azadirol的mp.109～112℃,FAB质谱m/z〔MH〕~+545,高分辨质谱m/z〔M-H_2O〕~+
The india Azadirachta indica can be seen everywhere in the Indo-Pakistan sub-continent. Almost every part of the tree is used to treat diseases in the private sector. Many components have been separated from it, some of which have significant anti-infection, anti-rheumatic, anti-ulcer, and anti-pyretic properties. , anti-tumor and insecticidal effects. This paper reports that fresh, unpulverized, mature peels are repeatedly extracted with ethanol at room temperature, ethanol extracts are partitioned with water-ethyl acetate, and the ethyl acetate layer is repeatedly treated with various solvents, combined with column chromatography, thin layers, etc. A new tetracyclic triterpene compound azaditol [1], a kulac-tone that has been segregated from Melicaagedarach and a known compound ipoxyazdiradione, was obtained. Azadirol mp. 109 to 112°C, FAB mass spectrum m/z (MH)~+545, high resolution mass spectrum m/z [M-H_2O]~+