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目的探讨放疗后残留肝癌采用高强度聚焦超声(HIFU)治疗的效果。方法 40例放疗后残留肝癌的患者,采用HIFU治疗,分析治疗前后临床资料。结果平均随访12个月,死亡5例,其中死于心脑血管意外2例,局部肿瘤控制失败3例;其他35例患者病情控制出院。外周血甲胎蛋白(AFP)治疗前为(2424.7±302.6)μg/L,治疗2周后为(166.8±124.2)μg/L,与治疗前比较明显降低,差异有统计学意义(P<0.05)。治疗前肿瘤直径为(3.8±1.8)cm,治疗后为(1.7±1.6)cm,较治疗前明显缩小,差异有统计学意义(P<0.05)。结论针对适形、立体定向放疗后出现的残留肝癌,采用HIFU治疗,具有较高有效性和安全性,为残留肝癌提供了新的治疗途径,对保障患者生命健康和生存质量有非常重要的意义。
Objective To investigate the effect of high intensity focused ultrasound (HIFU) treatment on residual liver cancer after radiotherapy. Methods Forty patients with residual HCC after radiotherapy were treated with HIFU and the clinical data were analyzed before and after treatment. Results The average follow-up of 12 months, 5 deaths, of which 2 died of cardiovascular and cerebrovascular accidents, 3 cases of local tumor failure control; the other 35 patients discharged from hospital. The level of AFP in peripheral blood was (2424.7 ± 302.6) μg / L before treatment and (166.8 ± 124.2) μg / L after 2 weeks of treatment, which was significantly lower than that before treatment (P <0.05) ). Before treatment, the diameter of the tumor was (3.8 ± 1.8) cm and (1.7 ± 1.6) cm after treatment, which was significantly smaller than that before treatment (P <0.05). Conclusion For HCC patients treated with HIFU after conformaltional and stereotactic radiosurgery, HIFU treatment is more effective and safe, providing a new therapeutic approach for residual HCC, which is very important for ensuring the life and quality of life of patients .