论文部分内容阅读
目的 对比BVP化疗配合放射治疗与单纯放疗治疗宫颈癌的疗效,探讨综合治疗在中晚期宫颈癌 中的疗效及安全性。方法 83例Ⅱ-Ⅳ中晚期宫颈癌患者分成两组,放疗同步化疗(A组)47例,在放疗同时给予 BVP方案(BLM30mgd1,VCR2mgd1,DDP40mgd1～3)化疗2～4周期,化疗第1天开始行放射治疗。单纯放疗 组(B组)36例,两组放射治疗均用6Mv-X线全盆对穿两大野照射DT25～30Gy,随后改成盆腔四野照射并加192 铱后装治疗。结果 A组和B组近期有效分别为93.6%和72.2%,两组的差异有显著性意义(χ2=7.10,P<0. 01)。A组和B组的5年生存率分别为72.3%和50%。差异有显著性意义(χ2=4.35,P<0.05)。毒性反应方 面,同步化放疗组高于单纯放疗组,尤以造血系统和消化道反应为主,但大部分能够耐受。结论 中晚期宫颈癌患 者BVP方案同步放化疗可提高局部控制率和提高生存率。
Objective To compare the curative effect of BVP chemotherapy with radiotherapy and radiotherapy alone on cervical cancer and to explore the curative effect and safety of comprehensive treatment in advanced cervical cancer. Methods 83 patients with stage Ⅱ-Ⅳ advanced cervical cancer were divided into two groups. Radiotherapy was performed in 47 patients with concurrent chemotherapy (group A). The patients were treated with BVP (BLM30mgd1, VCR2mgd1, DDP40mgd1 ~ 3) Start radiotherapy. Thirty-six patients in the radiotherapy group (group B) received DT25 ~ 30Gy radiotherapy with 6Mv-X radiographs, and then were treated with DT25 ~ 30Gy radiotherapy and then 192 IV radiotherapy. Results The recent effective rates in group A and group B were 93.6% and 72.2%, respectively, with significant differences between the two groups (χ2 = 7.10, P <0.01). The 5-year survival rates in groups A and B were 72.3% and 50%, respectively. The difference was significant (χ2 = 4.35, P <0.05). Toxicity, the synchronized radiotherapy group than the radiotherapy group, especially in the hematopoietic system and gastrointestinal reactions, but most can be tolerated. Conclusions The concurrent chemoradiotherapy with BVP in patients with advanced cervical cancer can improve the local control rate and improve the survival rate.