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通过临床观察和动物实验评价超微量肝素（１ｕｋｇ－１ｈ－１）对微循环障碍性疾病的疗效并探讨其作用机理。方法：选择新生儿硬肿症６４例，随机分为对照组３３例，治疗组３１例，比较超微量肝素疗效；建立大鼠内毒素休克模型，比较６５４－２及不同剂量肝素对微循环的作用。结果：超微量肝素可明显缩短硬肿患儿复温时间，硬肿消退时间和住院时间（Ｐ＜０．０１），使死亡率由２１．２％降至９．７％（χ２＝１１．１，Ｐ＜０．０１），无任何毒副作用；内毒素休克大鼠经超微量肝素治疗后各重要组织微血管通透性分值均有不同程度下降（Ｐ＜０．０５或０．０１），血清ＭＤＡ值接近正常对照组，电镜下肠系膜微血管形态基本恢复正常。结论：超微量肝素可有效改善微循环且作用优于常规及小剂量肝素，其作用机理可能与抗凝、抗血栓形成以及抗自由基损伤有关。
To evaluate the curative effect of 1ukg-1h-1 on microcirculation disorders through clinical observation and animal experiments and to explore its mechanism. Methods: Sixty-four neonates with sclerema were selected and randomly divided into control group (n = 33) and treatment group (n = 31). The model of endotoxic shock was established. The effects of 654-2 and different doses of heparin on microcirculation effect. Results: Ultramicro-heparin significantly shortened the rewarming time, edema time and hospitalization time in children with sclerosis (P <0.01), and reduced the mortality rate from 21.2% to 9.7% (χ2 = 11). 1, P <0.01), without any toxic or side effects. The microvessel permeation scores of all important tissues in endotoxic shock rats decreased to different extents (P <0.05 or 0.01) , Serum MDA values close to the normal control group, mesenteric microvascular morphology returned to normal under electron microscopy. Conclusion: Ultramicro heparin can effectively improve microcirculation and its effect is superior to conventional and low-dose heparin. Its mechanism may be related to anticoagulation, antithrombosis and anti-free radical damage.