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目的探讨低血糖并发痫性发作的机制,临床表现及治疗转归。方法回顾分析宝鸡市中心医院神经内科2007-2010年收治的12例低血糖并发痫性发作患者的临床资料。结果该病可发生于任何年龄组,临床表现多样,部分病例伴有神经系统局灶定位体征,3例脑电图见局灶性痫性放电。主要的病因是降糖药物应用不当,2例发现胰岛细胞瘤,经静脉注射高渗葡萄糖后可迅速终止癫痫发作,正规降糖治疗或切除胰岛细胞瘤后未再出现痫性发作。结论部分痫性发作是由低血糖引起,临床确诊癫痫时,应注意排除未正规治疗的糖尿病、胰岛细胞瘤或由其他原因所致低血糖导致的脑代谢功能紊乱。
Objective To investigate the mechanism, clinical manifestation and outcome of hypoglycemic complicated seizures. Methods The clinical data of 12 patients with hypoglycemic complicated seizures who were treated in Department of Neurology, Central Hospital of Baoji from 2007 to 2010 were retrospectively analyzed. Results The disease can occur in any age group, clinical manifestations of diversity, some cases with signs of focal neurological localization, 3 cases of epileptic seizures seen EEG. The main etiology is improper use of hypoglycemic drugs, 2 cases of islet cell tumor found that intravenous hypertonic glucose can be terminated immediately after seizures, regular hypoglycemic treatment or resection of islet cell tumor did not appear after epileptic seizures. Conclusion Some of the seizures are caused by hypoglycemia. In the clinical diagnosis of epilepsy, caution should be taken to exclude disorders of brain metabolism caused by diabetes, islet cell tumor or hypoglycemia caused by other reasons.