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目的:观察东菱克栓酶(DF-521)治疗突发性耳聋的临床疗效。方法:将40例突聋病人随机分为两组,DF-521组为DF-521首次10Bu加到100mL0.9％生理盐水中静脉缓滴,隔日给5Bu,连用4次为1疗程。对照组给复方丹参20mL加入10％葡萄糖250mL+低分子右旋糖酐500mL静脉缓滴,每天1次,14d为1疗程。结果:DF-521组总有效率为75％(15/20)、治愈率为25％,复方丹参组总有效率为45％(9/20)、治愈率为10％。(P<0.05)东菱克栓酶疗效明显优于对照组。结论:表明东菱克栓酶治疗突发性耳聋是较理想的药物。
Objective: To observe the curative effect of DF-521 in the treatment of sudden deafness. Methods: Forty patients with sudden deafness were randomly divided into two groups. DF-521 group was given DF-521 for the first time and added to 100uu 0.9% 0.9% saline for the first time. The control group to the compound Danshen 20mL added 10% glucose 250mL + low molecular weight dextran 500mL intravenous slow, once daily, 14d for a course of treatment. Results: The total effective rate was 75% (15/20) in DF-521 group, the cure rate was 25%, the total effective rate was 45% (9/20) in compound Danshen group and the cure rate was 10%. (P <0.05) Curative effect of cumame significantly better than the control group. Conclusion: It is indicated that rhubarb thrombin is an ideal medicine for sudden deafness.