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研究新生儿硬肿症５３例，各种原因所致肺出血１２例。检测了ＴＸＢ２（血栓素Ａ２－ＴＸＡ２的稳定衍生物）、６－Ｋ－ＰＧＦ１α（前列环素Ｉ２－ＰＧＩ２稳定衍生物）、ＰＣ－ＡＣＡ（蛋白Ｃ抗凝血活性）。其结果，新生儿硬肿症早期ＴＸＢ２升高，ＰＣ－ＡＣＡ在低体温时活性低，揭示本症存在着高凝趋势。肺出血病人６－Ｋ－ＰＧＦ１α升高，有些病人是在肺出血前检出的，提示此项可做为肺出血早期监测指标，但指标水平及出现时间等应进一步研究。肺出血病人Ｔ／Ｐ（ＴＸＢ２／６－Ｋ－ＰＧＦ１α以下简称Ｔ／Ｐ）比例失调，本研究证明新生儿硬肿症及肺出血存在血小板激活／破坏及血管内皮功能改变，有出凝血功能障碍。
Study 53 cases of neonatal sclerema, 12 cases of pulmonary hemorrhage due to various reasons. TXB2 (stable derivative of thromboxane A2-TXA2), 6-K-PGF1α (prostacyclin I2-PGI2 stable derivative), PC-ACA (protein C anticoagulant activity) were tested. As a result, early TXB2 levels in neonatal sclerodema and low activity of PC-ACA in hypothermia indicate that there is a hypercoagulability trend in this disease. Pulmonary hemorrhage patients 6-K-PGF1α increased, some patients were detected before pulmonary hemorrhage, suggesting that this can be used as an early indicator of pulmonary hemorrhage, but the level of indicators and the timing of occurrence should be further studied. Pulmonary hemorrhage in patients with T / P (TXB2 / 6-K-PGF1α hereinafter referred to as T / P) imbalance, the study shows that neonatal scleredema and pulmonary hemorrhage platelet activation / destruction and changes in endothelial function, there are coagulation disorders .