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目的探讨血清超敏C反应蛋白(high-sensitive C-reactive protein,hs-CRP)与急性脑血管疾病的关系。方法抽取入选患者和健康者静脉血,检测急性脑血管病患者和健康者血清hs-CRP水平,并进行比较。结果脑梗死组、脑出血组与对照组比较血清hs-CRP水平升高,但脑出血组与脑梗死组比较无显著差异,大梗死患者的血清hs-CRP比小梗死升高明显,差异均有统计学意义(P<0·05);短暂脑缺血发作(TIA)组与对照组比较,差异无统计学意义(P>0·05)。结论血清hs-CRP水平与脑血管疾病密切相关,可预测脑血管疾病的危险性,并可作为监测病情和预后判断的指标。应该注意的是,血清hs-CRP浓度的变化是组织受损时的一项非特异性反应,必需在排除了引起血清hs-CRP变化的其他原因后才能做出正确的判断。
Objective To investigate the relationship between serum high-sensitive C-reactive protein (hs-CRP) and acute cerebrovascular disease. Methods Venous blood samples from patients and healthy volunteers were collected for detection of serum hs-CRP levels in patients with acute cerebrovascular disease and healthy controls. Results Compared with the control group, the level of hs-CRP in the cerebral infarction group and the cerebral hemorrhage group was increased, but there was no significant difference between the cerebral hemorrhage group and the cerebral infarction group. The hs-CRP level in the infarct group was significantly higher than that in the small infarction group (P <0.05). There was no significant difference between the TIA group and the control group (P> 0.05). Conclusion Serum hs-CRP level is closely related to cerebrovascular disease, which can predict the risk of cerebrovascular disease and can be used as an indicator to monitor the disease and prognosis. It should be noted that changes in serum hs-CRP concentrations are a nonspecific response to tissue damage that must be accounted for by excluding other causes that contribute to changes in serum hs-CRP.