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目的探讨宫外孕患者应用甲氨喋呤联合米非司酮及宫外孕Ⅱ号治疗的效果。方法将我科2004年10月至2012年10月收治的124例孕5～10周宫外孕患者随机分为治疗组和对照组,每组各62例。对照组患者采用甲氨喋呤及宫外孕Ⅱ号治疗;而治疗组患者采用甲氨喋呤联合米非司酮及宫外孕Ⅱ号治疗;观察比较两组治疗效果。结果治疗组患者在血β-HCG降至正常时间和包块缩小至消失时间比对照组明显缩短,治愈率也高于对照组,两组比较差异有统计学意义(P<0.05)。结论宫外孕采用甲氨喋呤联合米非司酮及宫外孕Ⅱ号保守治疗,较之于单纯使用甲氨喋呤及宫外孕Ⅱ号治疗,具有疗效确切、迅速解除宫外孕症状的优势,说明米非司酮在治疗宫外孕方面具有一定的优势。
Objective To investigate the effect of methotrexate combined with mifepristone and ectopic pregnancy on patients with ectopic pregnancy. Methods A total of 124 pregnant women with ectopic pregnancy from 5 weeks to 10 weeks from October 2004 to October 2012 were randomly divided into treatment group and control group, with 62 cases in each group. The patients in the control group were treated with methotrexate and ectopic pregnancy Ⅱ, while the patients in the treatment group were treated with methotrexate combined with mifepristone and ectopic pregnancy Ⅱ. The therapeutic effect was observed and compared between the two groups. Results Compared with the control group, the β-HCG decreased to normal time and the time to disappear in the treatment group was significantly shorter than the control group, and the cure rate was also higher than that of the control group. There was significant difference between the two groups (P <0.05). Conclusions Ectopic pregnancy with methotrexate combined with mifepristone and ectopic pregnancy Ⅱ conservative treatment, compared with the simple use of methotrexate and ectopic pregnancy Ⅱ treatment, with the exact effect of rapid elimination of ectopic pregnancy symptoms advantage, indicating that mifepristone In the treatment of ectopic pregnancy has some advantages.