【摘 要】
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Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane.Current therapeutic strategies for RA
【机 构】
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Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of
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Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane.Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines.Therefore,the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy.Nowadays,the nanocarrier system incorporated with stimuli-responsive property is being intensively studied,showing the potentially tremendous value of specific therapy.Stimuli-responsive (i.e.,pH,temperature,light,redox,and enzyme) polymeric nanomaterials,as an important component of nanoparticulate carriers,have been intensively developed for various diseases treatment.A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored.The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations.Herein,we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA.The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.
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