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目的:探讨与胚胎冻融及移植结局相关的因素,以提高冻融胚胎的移植妊娠率。方法:通过对676个冻融周期的胚胎解冻及移植结果进行分析,比较不同的受精方式、内膜准备方法、冷冻时的胚龄、冷冻胚胎解冻周期数对移植结局的影响。结果:不同受精方式的胚胎复苏存活率、卵裂球完整率、临床妊娠率及胚胎种植率比较差异无统计学意义(P>0.05)。不同的内膜准备方法、解冻次数的临床妊娠率及胚胎种植率比较差异无统计学意义(P>0.05)。D2胚胎与D3胚胎的胚胎存活率、完整率、种植率和妊娠率比较差异有统计学意义(P<0.05)。妊娠组的胚胎存活率和完整胚胎率与非妊娠组比较差异有统计学意义(P<0.05)。结论:胚胎存活率和完整胚胎率对冻融胚胎的移植结局有影响,D2胚胎比D3胚胎有较高的存活率、完整率、种植率和妊娠率。
OBJECTIVE: To explore the factors related to embryo freeze-thaw and transplantation outcomes to improve the pregnancy rate of frozen-thawed embryos. Methods: The effects of different fertilization methods, endometrial preparation methods, embryo age during freezing, and thaw cycles of frozen embryos on the outcome of transplantation were analyzed. Results: There was no significant difference in embryo resuscitation survival rate, blastomere complete rate, clinical pregnancy rate and embryo implantation rate among different fertilization modes (P> 0.05). There was no significant difference in clinical pregnancy rate and embryo implantation rate between different methods of endometrial preparation and thawing times (P> 0.05). D2 embryos and D3 embryos embryos survival rate, complete rate, implantation rate and pregnancy rate difference was statistically significant (P <0.05). Pregnancy group embryo survival rate and intact embryo rate compared with non-pregnancy group was significantly different (P <0.05). Conclusion: The survival rate of embryos and the rate of intact embryos affect the outcome of frozen-thawed embryos. D2 embryos have higher survival rate, complete rate, implantation rate and pregnancy rate than D3 embryos.