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目的 探讨晚期日本血吸虫病与肝炎的关系。 方法 采用 1∶ 1,1∶ 2配对病例 -对照研究的方法 ,两对照分别为慢性血吸虫病病人和正常人 ,共配 2 13对。调查被研究对象的一般情况、血吸虫病与肝炎患病情况、家属患肝炎情况 ,同时检测乙肝 5项指标。统计分析用 SAS6 .12版软件 ,方法为 χ2检验与条件 L ogistic回归分析。 结果 除 HBs Ab外晚期血吸虫病患者肝炎患病率、家属肝炎患病率、HBs Ag、HBc Ab、HBe Ag、HBe Ab、大三阳、小三阳的阳性率 (2 3.94 %、15 . 96 %、2 9.11%、37.0 9%、15 .0 2 %、38.5 0 %、4 .2 3%、19.72 % )均显著高于慢性血吸虫病患者 (9.39%、5 .6 3%、14 .0 8%、16 .90 %、7.5 1%、2 0 .19%、0、7.89% )和正常人 (7.5 1%、5 .16 %、15 .0 2 %、2 0 .19%、1.88%、19.2 5 %、0、9.86 % )(P均 <0 .0 5 ) ,经 L ogistic回归分析 ,晚期血吸虫病患者的大三阳和 HBe Ag阳性率的比值比 (OR)值分别达 2 0 .934和8.0 0 (晚血与正常人 1∶ 1配对 )。 结论 晚期血吸虫病与肝炎关系密切 ,可认为两者间存在相互促进的关系。
Objective To investigate the relationship between advanced Japanese schistosomiasis and hepatitis. Methods 1: 1, 1: 2 paired case-control study method, the two controls were chronic schistosomiasis patients and normal, matched with a total of 213 pairs. Survey of the general situation of the object of study, schistosomiasis and hepatitis prevalence, family members suffering from hepatitis, while testing five indicators of hepatitis B. Statistical analysis using SAS6 .12 version of the software, the method for χ2 test and conditional L ogistic regression analysis. Results The prevalences of hepatitis, familial hepatitis, HBsAg, HBcAb, HBeAg, HBeAbs, BMSCs and BMSCs in patients with advanced schistosomiasis except HBs Ab were 23.9%, 15.96% , 29.11%, 37.0 9%, 15.0%, 38.5%, 4.23%, 19.72%) were significantly higher than those of chronic schistosomiasis patients (9.39%, 5.33%, 14.080 %, 16.90%, 7.51%, 2.019%, 0,7.89%) and normal subjects (7.5%, 5.16%, 15.0%, 2.0%, 1.88% 19.25%, 0,9.86%) (P <0.05). The logistic regression analysis showed that the odds ratios (OR) of the positive rates of Daisanyang and HBeAg in patients with advanced schistosomiasis were 20%. 934 and 8.0 0 (late blood paired with normal 1: 1). Conclusions There is a close relationship between advanced schistosomiasis and hepatitis, and it can be considered that there is mutual promotion between the two.