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目的探讨腹膜外卵巢移位术与改良卵巢移位术对宫颈癌患者卵巢功能的影响。方法选取2010年3月至2015年9月间山东潍坊临朐县人民医院收治的140例宫颈癌患者,采用随机数表法将患者分为观察组和对照组,每组70例。观察组行改良卵巢移位术,对照组行腹膜外卵巢移位术。比较两组患者治疗前后孕酮(P)、卵泡刺激素(FSH)、黄体生成素(LH)及雌二醇(E)含量,并发症发生率及随访24周性生活满意度。结果两组患者治疗前P、FSH、LH及E值比较,差异均无统计学意义(均P>0.05)。两组患者治疗后较治疗前比较P值升高、FSH、LH和E值降低,但差异均无统计学意义(均P>0.05)。两组治疗后P、FSH、LH及E值比较差异无统计学意义(P>0.05)。观察组并发症发生率为10.0%,对照组并发症发生率为21.4%,观察组较对照组相比并发症发生率明显降低,差异有统计学意义(P<0.05)。对照组性生活满意率为81.4%,观察组性生活满意率为91.4%,观察组较对照组比较性生活满意明显提高,差异有统计学意义(P<0.05)。结论腹膜外卵巢移位术与改良式卵巢移位手术治疗宫颈癌都可以有效保留卵巢的功能,改良式卵巢移位术可减少并发症的发生,显著提高患者术后性生活满意度。
Objective To investigate the effect of extraperitoneal ovarian transposition and modified ovarian transposition on ovarian function in patients with cervical cancer. Methods A total of 140 cervical cancer patients were treated in Linqu County People’s Hospital of Weifang, Shandong Province from March 2010 to September 2015. The patients were divided into observation group and control group by random number table method, with 70 cases in each group. The observation group underwent modified ovarian transposition and the control group underwent extraperitoneal ovarian transposition. The levels of progesterone (P), follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E) were compared between the two groups before and after treatment. The incidence of complications and satisfaction with 24-week follow-up of sexual life were compared. Results There was no significant difference in P, FSH, LH and E between the two groups before treatment (all P> 0.05). After treatment, P value and FSH, LH and E in both groups were significantly higher than those before treatment, but the differences were not statistically significant (all P> 0.05). There was no significant difference in P, FSH, LH and E between the two groups after treatment (P> 0.05). The incidence of complications in the observation group was 10.0%, the incidence of complications in the control group was 21.4%, and the incidence of complications in the observation group was significantly lower than that in the control group (P <0.05). Satisfaction rate of sexual life in control group was 81.4%, satisfaction rate of sexual life in observation group was 91.4%. Satisfaction of observation group was significantly higher than that of control group, and the difference was statistically significant (P <0.05). Conclusion Extraperitoneal ovarian transposition and modified ovarian transposition for the treatment of cervical cancer can effectively retain the ovarian function. Modified ovarian transposition can reduce the incidence of complications and significantly improve the postoperative sexual satisfaction.