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目的:检测盘状结构域受体1(DDR1)在垂体腺瘤中的蛋白表达水平并探讨其临床意义。方法:收集81例手术切除的垂体腺瘤和5例正常垂体前叶组织标本及其临床资料,应用免疫组化SP法检测和比较其DDR1蛋白的表达情况,并分析垂体腺瘤组织中DDR1蛋白的表达与患者临床及病理特征的相关性。结果:垂体腺瘤组织中DDR1的阳性表达率为64.2%(52/81例);侵袭性垂体腺瘤组织中DDR1蛋白的阳性表达率显著高于非侵袭性垂体腺瘤(x2=16.40,P=0.000);功能性垂体腺瘤组织中DDR1蛋白的阳性表达率显著高于无功能性垂体腺瘤(x2=18.06,P=0.000);直径≥10 mm垂体腺瘤组织中DDR1蛋白的阳性表达率显著高于直径<10 mm的垂体腺瘤(x2=11.68,P=0.003)。结论:DDR1的表达与垂体腺瘤的侵袭性、内分泌类型和肿瘤大小有关,可能在垂体腺瘤发病机制中起重要作用。
Objective: To detect the protein expression of discoid domain receptor 1 (DDR1) in pituitary adenomas and to explore its clinical significance. METHODS: Totally 81 surgical specimens of pituitary adenoma and 5 normal pituitary adenomas were collected and their clinical data were collected. The expression of DDR1 protein was detected by immunohistochemical SP method and the expression of DDR1 protein in pituitary adenomas The correlation between the expression and clinical and pathological features of patients. Results: The positive rate of DDR1 in pituitary adenomas was 64.2% (52/81). The positive rate of DDR1 protein in invasive pituitary adenomas was significantly higher than that in non-invasive pituitary adenomas (x2 = 16.40, P = 0.000). The positive rate of DDR1 protein in functional pituitary adenomas was significantly higher than that in non-functional pituitary adenomas (x2 = 18.06, P = 0.000). The positive rate of DDR1 protein in pituitary adenomas was Rates were significantly higher than those of pituitary adenomas <10 mm in diameter (x2 = 11.68, P = 0.003). Conclusion: The expression of DDR1 is related to the invasiveness, endocrine types and tumor size of pituitary adenomas, which may play an important role in the pathogenesis of pituitary adenomas.