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采用随机对照多中心临床研究 ,使用氨苄青霉素 /丙磺舒胶囊治疗急性细菌性感染患者 10 4例。其中 5 0例与进口氨苄青霉素胶囊治疗同类患者 5 0例进行随机对照试验 ;5 4例为开放性试验。试验组和对照组痊愈率与有效率均无显著性差异。试验组细菌清除率为 86 7% ,与对照组虽无显著性差异 ,但其耐药率为 7 1% ,低于对照组。不良反应发生率为 5 0 %。结果表明氨苄青霉素 /丙磺舒胶囊是一高效、安全的抗菌素。
A randomized controlled multicenter clinical trial was conducted in which 104 cases of acute bacterial infection were treated with ampicillin / probenecid capsules. 50 cases were treated with imported ampicillin capsules in 50 patients with similar randomized controlled trials; 54 cases were open-label test. There was no significant difference in cure rate and effective rate between the experimental group and the control group. The bacterial clearance rate of the experimental group was 86.7%, which was not significantly different from that of the control group, but the drug-resistant rate was 71% lower than that of the control group. The incidence of adverse reactions was 50%. The results show that ampicillin / probenecid capsules is a highly effective and safe antibiotic.