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Chronic experiments were made on eighteen dogs with Thomas pancreatic fistula andgastric fistula. Both in chronic and acute experiments the degenerated right cervical vagusnerve was stimulated by electrical shock and the endogenous secretin and CCK was releasedby means of duodenal acidification (D. A.). The exogenous secretin, atropine and lidocainewere infused to analyse the interrelationship of neurohormones in the pancreatic exocrinesecretion. The results were as follows. In chronic experiments the pancreatic secretory la-tency was shorter and volume larger than that in acute experiments induced by D. A. Thedifference is very significant (P<0.001). Both vagotomy and atropine significantly inhibitedpancreatic secretion induced by D. A. (P<0.01). Lidocaine infused into duodenum inhibitedpancreatic secretion induced by D. A. as well. When vagal stimulation was combined withD. A., either simultaneously or successively, the pancreatic secretion was increased morethan the additive sum obtained by separate
Chronic experiments were made on eighteen dogs with Thomas pancreatic fistula andgastric fistula. Both in chronic and acute experiments the degenerated right cervical vagusnerve was stimulated by electrical shock and the endogenous secretin and CCK was released by means of duodenal acidification (DA). The exogenous secretin, atropine and lidocainewere infused to analyze the interrelationship of neurohormones in the pancreatic excretionship of neurohormones in the pancreatic excretion. The results were as follows. In chronic experiments the pancreatic secretory la-tency was shorter and volume larger than that in acute experiments induced by DA Thedifference is very significant (P < 0.001). Both vagotomy and atropine significantly inhibited pancreatic secretion induced by DA (P <0.01). Lidocaine infused into duodenum inhibited pancreatic secretion induced by DA as well. When vagal stimulation was combined with D. A., either simultaneously or successively, the pancreatic secretion was increased morethan the additive sum obt ained by separate