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近几个月来,本刊编辑部又陆续收到全国各地广大读者的一批来信,我们表示感谢。由于篇幅有限,只能摘登,希予谅鉴,深表歉意。一、制剂工艺方面浙江省金华卫生学校董嘉德来信对《关于丹参注射液工艺改进》一文(本刊82年3期)所采用的改良明胶法去除鞣酸,解决肌注刺激性、沉淀问题,提出异议,认为可在水煎液第一次乙醇处理回收乙醇后,用蒸馏水稀释,调节pH4～5,再加明胶或鸡蛋清水溶液来沉淀鞣质。因为明胶属于蛋白质,具有不溶于高浓度乙醇的性质。该校曹飞云也来信说,由于穿心莲的有效成分难溶于氯仿及水,因此用水提取氯仿萃法所制得的穿心莲注射液,含内酯量几乎很微。而采用乙醇提取、调整乙醇浓度达50%除去叶绿素等杂质。在醇液中加
In recent months, the editorial department of the journal has received a series of letters from readers across the country one after another. We are grateful. Due to limited space, I can only excerpt and I would like to express my profound apologies. First, the preparation process Zhejiang Jinhua Health School Dongjiade letter to the “Process Improvement on Danshen Injection” (Journal 82 Issue 3) used in the improved gelatin method to remove tannic acid, to solve the problem of intramuscular injection irritation, sedimentation, The objection was raised that the first ethanol treatment in water decoction can be used to recover ethanol, then diluted with distilled water, adjusted to pH 4 to 5, and gelatin or egg white water solution added to precipitate tannin. Because gelatin is a protein, it has the property of being insoluble in high concentrations of ethanol. The school’s Cao Feiyun also wrote that because the effective components of Andrographis paniculata are hardly soluble in chloroform and water, the extract of Andrographis penis L. produced by extracting water with chloroform has a very low content of lactones. The use of ethanol extraction, adjust the ethanol concentration of 50% to remove impurities such as chlorophyll. Add in alcohol