论文部分内容阅读
[目的]研究限食对老龄大鼠抗衰老的生物效应,并探讨其可能机制。[方法]雌性11月龄SD大鼠34只,随机分为3组,分别给予实验组大鼠对照组食量的80%和60%,6个月后测量血清SOD、MDA、脑组织MAO、NO及肝细胞凋亡指数。[结果]实验组大鼠血清SOD、脑组织NO活性较对照组明显提高(P﹤0.05);血清MDA水平、脑组织MAO活性、肝细胞凋亡指数较对照组显著降低(P﹤0.01)。[结论]自老龄期开始限食,对大鼠具有抗衰老的生物学效应。
[Objective] To study the biological effect of food restriction on anti-aging of aging rats and to explore its possible mechanism. [Methods] 34 female 11-month-old SD rats were randomly divided into three groups, which were given 80% and 60% of the experimental rats’ food intake respectively. After 6 months, serum SOD, MDA, brain tissue MAO, NO And hepatocyte apoptosis index. [Results] The levels of serum SOD and brain tissue NO in experimental group were significantly higher than those in control group (P <0.05). The level of serum MDA, the activity of MAO and the index of hepatocyte apoptosis in experimental group were significantly lower than those in control group (P <0.01). [Conclusion] From the age of the beginning of the limit of food, has the anti-aging biological effects in rats.