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目的 :探讨不同运动量对糖尿病前期3年转归的影响,为糖尿病前期人群选择正确的运动量提供参考依据。方法:选取2011年4月至11月参与四川泸州地区2型糖尿病患者肿瘤发生风险的流行病学调查研究中基线调查者,其中确诊为糖尿病前期者1 088人,糖尿病前期及糖尿病诊断依据《中国2型糖尿病防治指南(2013年)》,按《体育活动等级量表(PARS-3)》将纳入的糖尿病前期人群分为大运动量组(n=79)、中等运动量组(n=628)、小运动量组(n=154)、不运动或基本不运动组(n=227),对其进行3年的随访并观察其转归情况。结果:转归为糖尿病者188人(17.2%),转归为正常糖耐量者391人。其中不运动或基本不运动组转归为糖尿病者55人(24.2%),小运动量组转归为糖尿病者23人(14.9%),中等运动量组转归为糖尿病者93人(14.8%),大运动量组转归为糖尿病者17人(21.5%);中等运动量组随访的空腹血糖及口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)2 h血糖分别为(5.50±0.80)mmol/L和(8.50±2.43)mmol/L,明显低于基线值。Logistic回归分析显示,与不运动或基本不运动组相比,小运动量组转归为糖尿病的风险降低9.3%(OR=0.556,95%CI=0.321~0.964),中等运动量组转归为糖尿病的风险降低9.4%(OR=0.559,95%CI=0.381~0.819)。结论:在糖尿病前期阶段,缺乏运动增加转归为糖尿病的风险,小运动量及中等运动量与糖尿病转归风险降低相关。
Objective: To investigate the effect of different amount of exercise on the outcome of 3-year pre-diabetes mellitus, and to provide a reference for choosing the right amount of exercise in the pre-diabetics. Methods: Baseline survey participants who participated in the epidemiological investigation of the risk of developing type 2 diabetes in Luzhou district of Sichuan Province from April to November 2011 were selected. Among them, 1 088 were diagnosed as pre-diabetes, and the diagnosis of pre-diabetes and diabetes was based on “China The pre-diabetic population was divided into large exercise group (n = 79), moderate exercise group (n = 628) according to ”Physical Activity Rating Scale (PARS-3) Small amount of exercise group (n = 154), no exercise or basic non-exercise group (n = 227) were followed up for 3 years and the outcome was observed. Results: 188 patients (17.2%) were transferred to diabetes, and 391 were normal glucose tolerance. Among them, 55 (24.2%) with no exercise or no exercise group had diabetes, 23 (14.9%) with small amount of exercise, 93 (14.8%) with moderate exercise, 17 cases were diabetic (21.5%) in the large exercise group. The fasting blood glucose and oral glucose tolerance test (OGTT) 2 h blood glucose in the moderate exercise group were (5.50 ± 0.80) mmol / L and 8.50 ± 2.43) mmol / L, significantly lower than the baseline value. Logistic regression analysis showed that the risk of diabetes was reduced by 9.3% (OR = 0.556, 95% CI = 0.321-0.964) in the low exercise group compared with no exercise or basic non-exercise group, and the moderate exercise group was diabetic Risk decreased by 9.4% (OR = 0.559, 95% CI = 0.381-0.819). CONCLUSIONS: In the pre-diabetes stage, the lack of exercise increases the risk of becoming diabetic, with small amounts of exercise and moderate amounts of exercise associated with reduced risk of diabetes.