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２８例肝豆状核变性（ＨＬＤ）患者治疗前与中药肝豆汤配合西药驱铜治疗２个月后，分别应用韦氏成人智力量表（ＷＡＩＳ－ＲＣ）测定，对其智商变化进行对比观察，并选３０例为健康对照组。结果表明ＨＬＤ患者言语智商（ＶＩＱ）、操作智商（ＰＩＱ）及全量表智商（ＦＩＱ）较对照组普遍显著降低（Ｐ均＜０．００５），尤以视空间障碍更为突出，证明铜离子在ＨＬＤ脑内沉积不仅损害神经运动功能且严重损害智能。经中西医结合治疗后总体智力水平显著提高（ＶＩＱ、ＰＩＱ、ＦＩＱ的Ｐ值均＜０．００１），其中以ＰＩＱ各项分测验得分提高尤为突出（Ｐ均＜０．００１），说明治疗后ＨＬＤ的智力与锥体外系症状同样有效。本研究还提示ＨＬＤ的病程越长，智力损害的程度越严重，及早治疗则智商水平的恢复更易接近正常标准。
28 cases of Wilson’s disease patients with hepatolenticular degeneration (HLD) before treatment and the Chinese medicine liver bean soup with western medicine drive copper treatment for 2 months, respectively, using the Webster adult intelligence scale (WAIS-RC) determination of changes in their IQ were observed , And 30 cases were selected as healthy control group. The results showed that the VIQ, PIQ and FIQ in HLD patients were significantly lower than those in the control group (all P <0.005), especially in visual space disorders, which showed that copper ions in Brain deposition in HLD not only damages neuromotor function but also severely compromises intelligence. After treatment with TCM and Western medicine, the overall level of intelligence was significantly increased (PQ values of VIQ, PIQ and FIQ were all <0.001). The score of PIQ was significantly higher (all P <0.001), indicating that after treatment HLD intelligence and extrapyramidal symptoms are equally effective. The study also suggests that the longer the duration of HLD, the more severe the degree of mental impairment, early treatment is more likely to return to normal levels of IQ recovery.