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目的观察小剂量红霉素治疗早产儿喂养不耐受的临床效果。方法将出现喂养困难的早产儿随机分成治疗组和对照组,治疗组常规予红霉素3~5 mg/(kg.次),3次/d;对照组予吗丁啉口服治疗。观察两组患儿在喂养后的呕吐次数、鼻饲奶剩余量、体重增加、奶量增加情况、早产儿并发症及住院天数情况。结果治疗组予小剂量红霉素治疗后,患儿呕吐次数、鼻饲剩奶量、早产儿并发症及住院天数均较对照组明显减少;体重增加、奶量增加均较对照组明显增快。治疗组与对照组比较差异有统计学意义(P<0.01)。结论小剂量红霉素治疗早产儿喂养不耐受有明显疗效。
Objective To observe the clinical effect of low-dose erythromycin in feeding intolerance in preterm infants. Methods Premature infants with feeding difficulty were randomly divided into treatment group and control group. The treatment group was routinely given erythromycin 3 to 5 mg / (kg) times 3 times daily, and the control group was treated with domperidone orally. The number of vomiting, the remaining amount of nasal milk, the weight gain, the increase of milk volume, the complications of complication and days of hospitalization were observed in two groups. Results After treatment with low dose of erythromycin, the number of vomiting, the amount of nasal feeding milk, the complications of premature infants and days of hospitalization were significantly decreased in the treatment group compared with the control group. The body weight gain and milk yield increased significantly compared with the control group. The difference between the treatment group and the control group was statistically significant (P <0.01). Conclusion Small doses of erythromycin in treating premature infants with intolerance have a significant effect.